Hypodermic syringe body structure

ABSTRACT

A hypodermic syringe body structure including a plastic barrel open at one end and having an integral sleeve extending inwards from its other end, a separately formed plastic inner tubular member is arranged within the barrel and connected therewith so that at least a portion thereof is within the sleeve, one of the barrel and tubular member having an integral tubular extension projecting outwards of the other end of the barrel and which extension includes a frangible portion and a bore for receiving a cannula. One of the inner tubular member and the sleeve has a connector thereon for connection with the connector on the stopper of a liquid medicament container, and a piercing spike for piercing the stopper is connected to one of said tubular member and said connector so that the syringe body structure can be connected with a liquid medicament container to constitute a complete hypodermic syringe with the tubular extension and associated cannula being broken off after a single use.

[ 1 Oct. 30, 1973 HYPODERMIC SYRINGE BODY STRUCTURE [75] Inventors:George K. Burke; Kenneth Raines, I I

both of Bethlehem, Pa.

[73] Assignee: Burron Medical Products, Inc., Bethlehem, Pa.

22 Filed: Aug. 13, 1971 [21] Appl. No.: 171,624

[52] US. Cl 128/220, 128/221, 128/218 D [51] Int. Cl. A6lm 5/00, A61m5/04 [58] Field of Search 128/220, 221, 218 R,

128/218 N, 218 P, 218 M, 216, 272, 237, 218 D, 218 DA, 215; 206/43 [56]References Cited UNITED STATES PATENTS 1,718,602 6/1929 Smith 128/218 D1,833,598 11/1931 Smith 128/220 1,848,711 3/1932 Hall 128/220 1,929,24710/1933 I-Iein 128/220 2,497,562 2/1950 Smith 128/220 3,306,291 2/1967Burke 128/218 R 3,376,866 4/1968 Ogle 128/220 3,378,008 4/1968 Ogle128/220 3,469,581 9/1969 Burke 128/218 N 3,472,227 10/1969 Burke 128/2213,638,650 2/1972 Burke 128/221 FOREIGN PATENTS OR APPLICATIONS 1,938,8642/1970 Germany 128/220 Primary ExaminerRichard A. Gaudet AssistantExaminer-J. C. McGowan Anorney-Luke A. Mattare et al.

57 ABSTRACT A hypodermic syringe body structure including a plasticbarrel open at one end and having an integral sleeve extending inwardsfrom its other end, a separately formed plastic inner tubular member isarranged within the barrel and connected therewith so that at least aportion thereof is within the sleeve, one of the barrel and tubularmember having an integral tubular extension projecting outwards of theother end of the barrel and which extension includes a frangible portionand a bore for receiving a cannula. One of the inner tubular member andthe sleeve has a connector thereon for connection with the connector onthe stopper of a liquid medicament container, and a piercing spike forpiercing the stopper is connected to one of said tubular member and saidconnector so that the syringe body structure can be connected with aliquid medicament container to constitute a complete hypodermic syringewith the tubular extension and associated cannula being broken off aftera single use.

34 Claims, 33 Drawing Figures Oct. 30, 1973 United States Patent 1 Burkeet al.

PAH-immense 191a SHEET 1 OF 5 FIGZ.

ATTORNEYS PATENIED BB? 3 0 1975 SHEET 3 UF %8 E K MR VU m8 K E G R O E GKENNETH RAINES ATTORNEYS PAIENTED 0m 30 I975 ihlllllllllllll!HIHIFiiEFIG.30.

INVENTOR5 GEORGE K. BURKE 8| KENNETH RAINES ATTORNEYS PATENTED B61 30I973 SHEET 5 BF 5 FIG. 26.

Ill/

INVENTORS GEORGE K. BURKE a KENNETH RAINES BYV%QAA/M ATTORNEYSHYPODERMIC SYRINGE BODY STRUCTURE BACKGROUND OF THE INVENTION Thepresent invention relates to the hypodermic syringe or medicamentinjector of the type which embodies a syringe body for association witha medicament container in such a manner that the medicament can beexpelled through a cannula or needle associated with the syringe body.

Arrangements of this type are generally known, as exemplified by thedisclosures of U. S. Pats. to R. W. Ogle Nos. 3,376,866 and 3,378,008,dated Apr. 9, 1968 and Apr. 16, 1968, respectively.

In each of those known arrangements, the container for the liquidmedicament is to be so associated in use with a cannula carrying syringebody as to act as the expeller for the liquid.

In this art, the aspect of destroying the components after a singledosage is becoming more important than ever with the present dayincreases in contamination and infection possibilities and also toprevent any of the components being utilized for other than theoriginally intended purpose.

Further, the production of hypodermic syringe and vial or medicamentcontainer components on a large scale production basis, particularlyfrom organic plastic materials, such as polyethylene or polypropylene,present certain problems as regards molding the various necessarystructural features which enter into the assembly of and positioning ofthe cannula within the syringe body and relative to the plunger of themedicament container. In addition, the destruction capability of thecannula carrying syringe body gives rise to certain problems that can bemore readily overcome during manufacture if proper considerations aregiven thereto.

Therefore, it is desirable to provide a constructional arrangement of asyringe body which includes destructible aspects to limit usage to asingle dosage and which also includes features facilitating large scaleproduction on an economical basis as well as providing proper andaccurate assembly of a cannula and piercing spike relative to a syringebody and relative to the plunger of a medicament container.

STATEMENT OF THE INVENTION In the invention, there is provided a syringebody that includes a barrel forming tubular portion, an inner tubularportion that is to be operatively associated with a plunger or stopperof a liquid medicament container, and which is effectively integral withthe barrel forming portion, a tubular component that projects beyond thebase of the barrel that embodies a weakened portion effected duringmanufacture that permits ready separation of such tubular component fromthe barrel after a single dosage, a hollow piercing spike forcooperation with a plunger or stopper of a medicament container andmeans to mount a recipient needle relative to such tubular component.

The arrangement can be such that the tubular component embodying theweakened portion is formed simultaneously during molding with either theouter barrel forming portion, the inner tubular portion, or as aseparately molded tubular member. Further, a liquid transfer tube can beseparate from or integral with the inner tubular portion or theseparately molded tubular member, the piercing spike can be integralwith the transfer tube or the inner tubular portion, and the transfertube and piercing spike can be integrally formed in a single molding.Also, the tubular component that projects beyond the barrel can beformed to internally receive a fixed recipient needle, or constitute aluer taper having effectively externally integrally related therewith aluer lock adapter structure to receive replaceable needles.

Further, in the invention there is no patient piercing cannula or needlethat extends substantially throughout the barrel and also outwardly ofthe barrel a substantial extent. With prior art arrangements, thedestruction capability is diminished since a stainless steel needle asused in the art has to be severed or broken off. Also, in one aspect ofthe invention, a plastic transfer tube is provided with an integralpiercing spike so that the barrel and any component still associatedtherewith can be effectively incinerated after the outer frangible orweakened area connection of the tubular portion that projects beyond thebarrel and has the recipient metal needle associated therewith has beenbroken off.

Another feature of the invention consists in the provision of arelatively short inwardly extending centering boss or guide sleeve atthe base of the barrel for receiving the inner tubular portion thatcarries means at its outer end for cooperative connection with thestopper or plunger of a medicament container.

BRIEF DESCRIPTION OF THE DRAWINGS Further and more specific features andadvantages of the invention will be more readily apparent from thefollowing description taken in connection with the accompanying drawingsin which:

FIG. 1 is a longitudinal sectional view, partially broken away, of abarrel member according to one form of the invention;

FIG. 2 is a similar view illustrating a tubular structure forassociation within the barrel member of FIG. 1;

FIG. 2a is a fragmentary longitudinal sectional view illustrating amodification of the connecting end portion of the tubular structureshown in FIG. 2;

FIG. 3 is a cross-sectional view taken along lines 33 of FIG. 2;

FIG. 4 is a longitudinal sectional view of an assembled and integrallyconnected syringe body structure including the barrel member and tubularstructure of FIGS. 1 and 2;

FIG. 5 is a view similar to FIG. 1, illustrating a barrel memberaccording to another form of the invention;

FIG. 6 is a cross-sectional view taken along lines 6--6 of FIG. 5;

FIG. 7 is a view similar to FIG. 2, illustrating a tubular structure forassociation within the barrel member of FIG. 5;

FIGS. 8 and 9 are cross-sectional views taken, respectively, along lines8-8 and 9-9 of FIG. pierceable FIG. 10 is a longitudinal sectional viewof a combined liquid transfer tube and stopper piercing spike;

FIG. 10a is a fragmentary view illustrating a modification of thepiercing spike tip shown in FIG. 10;

FIG. 11 is a cross-sectional view taken along lines 11-11 of FIG. 10;

FIG. 12 is a view similar to FIG. 4 illustrating the components of FIGS.5, 7 and 10 in assembled and integral connected relationship;

FIG. 13 is a view similar to FIGS. 4 and 12 illustrating a third form ofthe invention and one that embodies a fixed recipient needle;

FIGS. 14 and 15 are fragmentary longitudinal sectional viewsillustrating modifications of the relationship of components shown inFIG. 13 in which the inner tubular member is formed with a needlereceiving socket;

FIGS. 16 and 17 are views similar to FIGS. 14 and 15 illustrating thetubular extensions from the barrel and inner tubular member shaped toreceive a removable needle;

FIG. 18 is a fragmentary longitudinal sectional view illustrating stilla further modification in which the transfer tube and piercing spike areseparately formed;

FIGS. 19 and 20 are views similar to FIG. 18 but illustratingmodifications of the piercing spike and connector assembly;

FIG. 21 is a longitudinal sectional view, partially broken away, andillustrating a barrel member of a syringe body structure in accordancewith a still further form of the invention;

FIG. 22 is a longitudinal sectional view of a crown member that carriesa transfer tube and embodies a frangible tubular extension and which isconnectable with the barrel member of FIG. 21;

FIG. 23 is a cross-sectional view taken on line 23-23 of FIG. 22;

FIG. 24 is a longitudinal sectional view of a connector member forassociation with the barrel member of FIG. 21;

FIG. 25 is an end view of the connector of FIG. 24;

FIG. 26 is a longitudinal sectional view, partly in elevation,illustrating an assembled hypodermic syringe body structure utilizingthe components of FIGS. 21 to 23;

FIG. 27 is a view similar to FIG. 26, but illustrating modifications inthe crown member of FIG. 22 and showing the connector member as beingformed with the barrel;

FIG. 28 is a view similar to that of FIG. 21 but illustrating theconnector member as an integral part of the inwardly extending tubularsleeve;

FIG. 29 is a view similar to FIG. 22 but illustrating a crown memberstructure including a frangible tubular extension and a tubular socketportion for receiving a fixed recipient needle;

FIG. 30 is a longitudinal sectional view of a shell member that engagesover and connects with the tubular socket portion so as to complete theformation of an epoxy resin receiving pocket for fixing the needle inposition; and having connected FIG. 31 is a view illustrating thecomponent parts of FIGS. 28 to 30 in assembled relation. member DETAILEDDESCRIPTION OF PREFERRED EMBODIMENTS Referring to the drawings, FIGS. 1to 4, the first embodiment of the syringe body of this inventionincludes three basic components comprising an outer tubular barrel A, aninner tubular sleeve structure B having means at its outer end forconnection with a stopper of a liquid medicament container and a liquidtransfer tube C having a piercing spike at its outer end for piercingthe stopper of such a medicament container when the syringe body isoperatively associated with such a container.

The outer barrel is molded from a suitable plastic material, such aspolypropylene or the like, and includes an outer wall 1 having integralfinger grasping extensions 2 at its outer end. The base 3 of the barrelis molded with an inwardly directed short guide sleeve 4 that isinternally tapered inwardly from its outer end to provide a taperedsurface 5 to later receive the sleeve structure B. The end of sleeve 4is chamfered at 6. Ribs, such as at 7, are molded between the exteriorof the guide sleeve 4 and the inner bottom surface of the base 3 of thebarrel. These ribs which may be three or more in number, usually four,are provided to strengthen the guide sleeve structure and minimizewobbling thereof during assembly and use of the components as describedhereinafter.

The base 3 is further provided with an externally projecting tubularportion 8 that is shaped to provide a ta pered bore 9 having a widenedinner portion 10 to define a seat 11 to receive the end of a liquidtransfer tube as setforth hereinafter. The exterior surface 12 oftubular portion 8 is tapered to constitute a conventional luer tapersurface. Further, the inner end of the bore 9, 10 is defined by anannular portion 13 that defines a groove 14 in the base 3 of the barrel.The inner surface of annular portion 13 is inwardly tapered and theouter surface is of reverse taper. An annular bead 15 is provided at theinner rim of the base portion that defines the outer limit of groove 14.This bead of plastic material is utilized in forming a sonic seal withthe tubular sleeve structure as later described. Surrounding theperiphery of tubular portion 8 is an enlarged portion 16 that receives aluer lock adapter. The relationship of such a luer lock adapter relativeto the projection or extension 8, 16 is as clearly shown and describedin my prior US. Pat. No. 3,542,024, dated Nov. 24, 1970 and entitledHYPODERMIC ASSEMBLY. To effect connection with a luer lock adapter, anannular bead 17 is provided on the end of sleeve-like portion 16. Ribs18 are provided between the interior of portion 17 and exterior of theinner end of tubular portion 8 to facilitate uniform shrinkage of thematerial and to prevent dimple formation during the molding operation.This relationship is shown and described in my prior US. Pat. No.3,306,291, dated Feb. 28, 1967, see FIGS. 20 and 22 thereof. Thus, theportions 8 and 16 constitute a projection or boss extending outwardly ofthe base 3 of the barrel and a frangible portion 19 joins the boss withthe base. This frangible portion 19 is formed between laterallyextending surfaces or shoulders 20 and 21. As shown, the portion 19 isof less thickness than the adjacent wall portions and is a prestressedarea, as described in said last-mentioned patent, so that the bossstructure or projection with or without an associated needle thereon canbe broken away from the barrel after a single use. with The tubularsleeve structure B, likewise of such molded plastic material, includesan elongated wall portion 22 having external strengthening ribs 23thereon for a substantial extent of its length. These ribs terminateshort of the inner end of sleeve B a distance sufficient to permitinsertion of sleeve B into guide sleeve 4 of the barrel A. The outer endportion of sleeve B is enlarged to provide an internally threaded socket24, the threads 25 of which cooperate wqth the external threads on astopper of a medicament container, generally indicated at MC in FIG. 4.The inner end of the sleeve B is provided with a bore 26 communicatingwith an internally extending liquid transfer tube receiving sleevearrangement 27. The bore is tapered inwardly from a projecting annularrim 28 to a bore portion 29 that accommodates such a transfer tube insuch a manner as to define a widened adhesive receiving pocket 30, anepoxy resin being a suitable adhesive.

The liquid transfer tube 31 has a piercing spike 32 at one end and isinserted in the bore 29 to extend through the pocket 30 and project pastthe end of the bead 28 a distance sufficient to seat against theshoulder 1 1 on the interior of the boss structure on the barrel A.Further, the bead 28 has a length such as to fit within groove 14 whenthe barrel A and inner sleeve structure B with the associated transfertube are integrally joined by sonic welding. A luer lock adapter 33, asshown in my prior U.S. Pat. No. 3,542,024, is sonic welded to and fitsover the enlarged portion 16 of the projection from the barrel A via thebead 17 engaging an internal flange 34 on such luer lock adapter. Theluer lock adapter has internal threads 35 for receiving and cooperatingwith lateral flange portions on a cannula and interconnected hub. Thisarrangement permits the use of different size needles, depending on thedesired flow rate to the patient.

In assembling this form of the invention, the outer barrel A, the innertubular sleeve structure B and the luer lock adapter 33 are separatelymolded. The liquid transfer tube 31 is then inserted within sleevestructure B and adhesively bonded therein. Then the transfertube-carrying sleeve structure B is inserted within barrel A until therim 28 fits within socket 14. A luer lock adapter 33 is then fitted overthe projection from the base of the barrel to engage the flange 34against bead 17. With the components so assembled, they are passed,while in vertical relation, through sonic welding apparatus toeffectively integrally unite, via material flow, the barrel A to thesleeve structure B and to the luer lock adapter 33. In effecting thiswelding, some of the material from the various beads, which act as sonicenergy directors, flows laterally to provide an effective seal as wellas integral bonding of the components together.

If desired, the energy directing beads can be discontinuous or formed asa series of individual pointed projections. Further, the energydirecting beads or projections can be formed on the flange 34 of theluer lock adapter rather than as at 17 on the boss or on the shouldersurrounding the rim 28 of the internal sleeve B rather than on the base3 of the barrel as shown at 15. Essentially there should be energydirecting beads or projections on one component in facing relation withsurfaces on the component to which it is to be effectively integrallyunited and sealed.

FIG. 2a illustrates a modification in which the connector is moldedseparately. Thus, the internally threaded connector 40 has a tubularextension 41 that is force fit within the outer end of the tubularmember 42. This member 42 is similar to the member B of FIG. 4. A snaplock connection between the extension 41 and the tubular member 42 isshown at 43. The bead for this connection can be formed on either theextension or the tubular member and the bead receiving groove in theother of these components. If the plastic material of the connector 40is conpatible with compatible plastic of the tubular member 42, theconnection can be a sonic weld connection as indicated diagrammaticallyat 44. Also, an adhesive connection can be utilized. The internal boreof the extension is generally conically shaped as at 45 to center atransfer tube spike member, such as shown at C in FIG. 4 whentheconnector 40 is secured to the tubular member 42.

The second form of the invention, FIGS. 5 to 12, incorporates the samegeneral components and includes a barrel A having a wall portion 101provided at its outer end with lateral finger engaging flange orextension portions 102. The base 103 is provided with a short inwardlyextending guide sleeve portion 104 of cylindrical external wall shapeand having a stepped internal bore including an outer portion 105 ofpolygonal, preferably hexagonal cross section, a beveled shoulder 106and an inner portion 107 having an energy directing bead 108 or a seriesof separate projections formed on the rim thereof. As shown, the wallthickness outwardly of the shoulder 106 is thinner than at the portion105. Stiffening ribs similar to ribs 7, FIG. 1, extend between the guidesleeve and base of the barrel.

To fit within this guide sleeve 104, there is separately molded atubular sleeve portion B that includes an elongated intermediate portion109 and an enlarged end portion 110 that is internally threaded as at111 for connection with the external threads on a stopper of a liquidmedicament container. The base 112 of the enlarged outer end portion isstepped to provide a circular recess 113 which receives a flange on alater described transfer tube. External strengthening ribs 114 areprovided on the intermediate portion of the tubular structure B. Theother end portion of such structure is externally stepped and shaped toprovide a first portion 115 of cylindrical outer shape extending betweena straight shoulder 116 that fits against the rim of guide sleeve 104,and a beveled shoulder structure 117 that merges with a second portion118 of hexagonal external shape. This portion 118 merges via a shoulder119 with an externally cylindrical frangible portion 120 delimited atits other end by shoulder 121. The final and external portion 122 of thetube structure constitutes a luer taper for receiving a luer lockadapter (not shown). A bead of material to form a seal with a liquidtransfer tube is provided at 123 on the interior of the portion 118 ofthe tubular structure.

The liquid transfer tube C is of molded plastic and is combined with apiercing spike and includes an intermediate portion 124 having externalstrengthening ribs 125 that fit this portion within the intermediateportion 109 of tubular structure B. The opposite ends of the ribs aretapered as shown. An enlarged flange 126 is provided at the inner end ofthe tube for fitting within the recess 113. The tube structure extendsbeyond the flange 126 and is shaped to provide a piercing spike 127having an anti-coring solid pointed tip 128 and at least two lateralapertures 129 to admit liquid into the inner bore or passage 130. Theface of flange 126 opposite spike 127 is provided with an energydirecting bead or a series of projections as at 131. The outer endportion 132 fits within tube portions 115 and 118 of tubular structure Bwith the chamfered or tapered ends of ribs 125 being at least close toan internal shoulder on the enlarged diameter intermediate portion 109of tubular structure B.

In assembling this form of the invention, the barrel A, tubularstructure B and combined transfer tube and piercing spike structure Cand a luer lock adapter,

are separately molded, interfitted together and then effectivelyintegrally united by sonic welding via beads or projections 131 on theflange 126, 123 on tubular structure B, and 108 on the guide sleeve 104of barrel A. Other beads or projections are provided on either shoulder121 on tubular structure B or on the base of the luer lock adapter tointegrally unite such adapter to the luer taper portion outwardly of thefrangible portion 120.

FIG. 10a illustrates a modified piercing spike 127 having a singlebarrel tip 128'.

The third basic form of the invention, FIG. 13, includes a barrel D, andan inner tubular structure E that combines the liquid transfer tube, theconnector for the stopper of the medicament container and the piercingspike in a single component. for a Thus, the barrel D includes a wallportion 201, finger engaging extensions 202 at one end thereof, a base203 at the other end and a guide sleeve 204 extending inwardly of thebase. Stiffening ribs as shown in FIGS. 1, 4 and 12 extend between thebase and guide sleeve. Projecting externally of the base is an extension205 that is shaped to provide a socket for cannula or needle. Theextension includes an inner frangible portion 206 of reduced wallthickness and defined between the outer surface 207 of the base and aninternal shoulder 208 on the extension. The needle receiving socket 209includes the epoxy resin receiving pocket 210 and an inner tubularextension 211 to accommodate a length of the needle 212. An externalsnap ring 213 is formed on the extension to cooperate with an internalgroove 214 on a cap or shell structure 215 which confines the needle andresin.

The inner tubular structure E includes an intermediate portion 216having external strengthening ribs 217 thereon and an end portion 218that fits within the guide sleeve portion 204 and has a reduced rimdefined by a shoulder 219 that fits within the bore through the base 203of the barrel. The other end portion of the tubular structure combines aconnector sleeve 220 having internal threads 221 thereon and a piercingspike 222 having a solid anti-coring point 223.

In assembly, the separately molded barrel D and tubular structure E areinterfitted after a needle has been epoxy resin bonded in the socket.Thereafter they are effectively integrally united by sonic weldingutilizing a bead or projections formed on either shoulder 219 or theadjacent base surface and a bead on the interior of guide sleeve portion204.

The last described arrangement contemplates a fixed recipient needle.While this form has such needle carried by the barrel, modificationsprovide the needle carrying socket on the inner tubular structure. Thus,as in FIG. 14, the base 203' of the barrel F has an internal guidesleeve 204' extending inwardly of the barrel radially outwards of thebore through the base. The internal tubular structure G is shaped toprovide a shoulder 219' for sealing and integrally uniting with thebarrel base 203', a frangible portion 230 between shoulders 231 and 232and a needle socket 209'.

. In another form where a fixed recipient needle is utilized, FIG. 15,the structure is akin to that shown in FIGS. 1 and 12, in which thebarrel or holder H is provided with an internally stepped guide sleeve300 that includes an inner surface portion 301 of polygonal, preferablyhexagonal, internal shape that accommodates a stepped plastic tubularinner sleeve I having a complementary polygonally shaped externalsurface portion 302 and which further includes an extension 303 thatprojects through and beyond the base of the barrel and which, duringmolding, is provided with a frangible intermediate portion 304. Theouter end of this tubular structure is shaped to constitute a socket 305for a fixed recipient needle. In the arrangements shown in FIGS. 14 and15, a cap such as shown at 215, FIG. 13, is utilized. that It islikewise believed clear that the structures shown in the last threedescribed forms can be further modified so that the tubular portionextending outwardly of the frangible portion, regardless of whether suchfrangible portion is embodied with the outer body or barrel or an innertubular member that passes through the guide sleeve and barrel, ismolded to constitute a tuer taper and has a shoulder to which is bondeda luer lock adapter, see FIGS. 16 and 17.

In one of these last described forms, FIG. 16, the luer taper 400, theshoulder 401 for receiving a luer lock adapter 402 and an intermediatefrangible portion 403 are molded integrally with the barrel J, whereasin still another form, FIG. 17, the luer taper 500, intermediatefrangible portion 503 and associated luer lock adapter receivingshoulder 501 for an adapter 502, are provided on the inner tubularstructure, the opposite end of which is shaped to provide the threadedconnecting portion and piercing spike as in FIG. 13. It is furtherbelieved clear that the structures of the first two describedembodiments, FIGS. 4 and 12, can be modified to accommodate a fixedrecipient needle by providing the tubular portion that extends outwardlyof the frangible portion with a shape so that it constitutes a needlesocket.

FIG. 18 illustrates a modification in which the transfer tube, piercingspike and inner tubular connector are separately formed. Thus, theinjection molded connector includes an enlarged connecting end 600having internal threads 601 for coupling with external threads on astopper of a medicament container. The base 602 of the connecting end isprovided with a recess as at 603. The piercing spike 604 is an injectionmolded plastic tubular member and includes a point or tip 605, anexternal flange 606 that fits .within recess 603 and a tubular extension607. The liquid transfer tube 608 is an extrusion and is connected tothe piercing spike by a sonic welding and sealing connectiondiagrammatically shown at 609. In effecting this connection, the energydirecting bead or a series of pointed projections can be formed oneither the end of the transfer tube or on the flange of the piercingspike. The connected transfer tube and piercing spike are fit within thetubular portion of the connectorso that flange 606 fits in recess 603and extension 607 fits within the elongated tubular part of theconnector. The parts are subjected to a sonic welding and sealingoperation to provide the sonic weld and seal as shown at 610. The energydirecting bead can be formed on either flange 606, similar to theshowing at 131 in FIG. 10 or on the base of recess 603. The transfertube is also sonically welded to the interior of the connector via abead such as at 123 in FIG. 7.

FIG. 18 only illustrates the connecting end of the connector, piercingspike and transfer tube assembly. The other end of tubular connector canbe the same as shown in FIG. 7 and include an external polygonal portionfor fitting within a guide sleeve of a barrel of the shape shown in FIG.5. Thus, the assembly would present the same appearance as shown at theupper end of FIG. 12, with the transfer tube 608 terminatingapproximately at the level of the outer surface of the base of thebarrel.

The tip 605 of piercing spike 604 can project slightly beyond the levelof the end of the connector or terminate within the threaded portion ofthe connector as shown in FIG. 12.

The structural relationship of FIG. 18 facilitates production in thatthe necessary small diameter transfer tubes can be extruded plasticmembers, while the piercing spike and tubular connector can be injectionmoldmgs.

Stiffening ribs can be provided on the exterior of the portion of thetubular connector that would extend between the inner end of the guidesleeve on the barrel and the base of the enlarged threaded portion ofthe connector.

FIG. 19 illustrates a modification of the connector, liquid transfertube and piercing spike assembly in which these latter two componentsare separately formed. Thus, the piercing spike member 604 is separatelymolded and includes a point 605', an external flange 606' that fitswithin a recess 603 of the connecting end 600'. The transfer tube 608has an enlarged outer end that accommodates a tubular extension 607' ofthe spike member. As shown, a snap lock connection 611 fastens the spikemember extension within the transfer tube. The bead or ribs of this snaplock can be on either the exterior of the tubular extension 607' or theinterior of the enlarged end of the transfer tube 608, with theaccommodating groove being in the other and facing surface of theseelements. If the plastic materials, of which the spike member, connectorend and transfer tube are made, are compatible, a sonic weld connection,as diagrammatically shown at 612, can be utilized. If desired, thevarious connections can be effected by an adhesive bonding utilizing anyof the adhesives well known in the art, such as an epoxy resin adhesive.

FIG. 20 illustrates another and similar modification in which thepolypropylene connector 700, the polypropylene liquid transfer tube 701and the flanged piercing spike 702 are separately formed. In this formof the invention, the piercing spike is molded from any of the ABSresins well known in the art and the connection between the piercingspike and the enlarged outer end 703 of the polypropylene transfer tubeis in the form of a snap lock connection shown at 704 since a sonic weldcannot be used as the plastics are incompatible. In this modification,it is desirable that there be relative rotation between the piercingspike, connector and transfer tube when the piercing spike is insertedin the externally threaded rubber plunger on the end of a medicamentcontaining vial and this plunger is rotated when being coupled to thethreads of the connector. This allows the piercing spike to go straightthrough the rubber of the plunger and eliminates any torque reaction onthe parts. A rubber seal ring 705 arranged between the tubular extension706 of the piercing spike and the enlarged outer end 703 of the transfertube provides an adequate seal and also permits the piercing spike torotate with the rubber plunger when the same is being threaded into theconnector.

The form of the invention shown in FIGS. 21 to 26 still retains theessential features of the syringe body structure of the invention butincorporates a modified arrangement of the main component elementsthereof.

Thus, in FIG. 21, the barrel member 800, molded from a plastic material,such as polypropylene, includes an outer wall 801 having integral fingergrasping lateral flanges or extensions 802 at its outer end. The base803 of the barrel is molded with an integrally formed inwardly extendingtubular portion or sleeve structure 804. The end of the sleeve structureadjacent the base 803 is shaped for cooperative connection with thecrown member shown in FIG. 22, and the end of the sleeve structureremote from the base is shaped for cooperative connection with theconnector structure shown in FIG. 24. The sleeve structure includes ashort portion 805 of larger diameter that merges at 806 with the majorwall 807 of the sleeve structure. An integrally formed and shapedinternal groove 808 is provided in the enlarged diameter portion toprovide the female part of a snap lock connection for receiving thecrown member. The base 803 has a chamfered surface 809 leading to oneside of the groove 808 to facilitate entry of the bead or rib portion ofthe snap lock connection. The interior of the major wall 807 of thesleeve structure inwardly of the juncture 806 is formed with a flute andrib formation at 810 for cooperation with a like formation on the crownmember as set forth hereinafter. Inwardly of the flute and rib formation810 but in close proximity thereto is an internal bead or ring 811 thatprovides a sterility seal and bacteria barrier when the crown member isforce fit within the tubular sleeve structure.

The outer end of the sleeve structure includes an internal and shapedring flange or bead structure 812 that constitutes the male member of asnap lock connection that is to be effected with the connector shown inFIG. 24. Outwardly of the bead structure 812, the inner surface of thesleeve structure is provided with a flute and rib formation at 813 forcooperative association with a flute and rib formation in the connectorof FIG. 24. Beyond the flute and rib formation, the extreme end .of thesleeve structure has an internal chamfer at 814 that extends to a thinend surface 815 that can constitute an energy director if the connectoris of a plastic that is compatible with the plastic of the sleevestructure.

The crown member CS of FIG. 22 includes a base 816 from one side ofwhich extend integraly formed, radially spaced, connectric shaped sleevestructures 817, 818 and 819. The outer sleeve structure 817 is short andprovided at its end with a shaped external flange or head structure 820that constitutes a male member and fits within the groove 808 of thesleeve structure of the barrel member and effects a snap lock connectiontherewith. The sleeve structures 818 and 819 are longer and ofapproximately the same axial extent inwardly of the base. The exteriorof the sleeve structure 818 is provided with an external flute and ribformation at 821 of a shape and length to cooperate in a tight fitrelation with the internal rib and flute formation 810 in the inner endof sleeve structure 804. The outer end portion 822 of sleeve structure818 is of reduced thickness and is externally chamfered at 823 so as tofacilitate entry of the crown member CS into the barrel member. Theinnermost sleeve structure 819 has a straight outer wall surface 824 anda shaped internal bore. The outer end of the bore includes threecontiguous portions of inwardly stepped formation of decreasing diametershown at 825, 826 and 827. The innermost portion 827 is merged with ashort portion 828 of square internal shape, which in turn merges with abore portion 829 that extends to a small bore portion 830 in the base816 of the crown structure. Internal rings or beads 831 are respectivelyprovided in the bore portions 825, 826 and 827 so that the internallysquare portion 828 and the stepped portion 825, 826 and 827 togetherconstitute a pocket structure to receive a liquid transfer tube memberthat is epoxy bonded thereinto. While the inner surface of bore portion828, as shown in FIG. 23, is a complete square, it could be shaped witha mold core that has four flats therein but which would not define acomplete square. However, this internal configuration and the ribs,rings or beads 831 provide an effective lock for the epoxy bonded liquidtransfer tube.

Also, integrally molded with the crown structure CS and projectingoutwardly of the side of the base thereof opposite sleeve structures817, 818 and 819, is a tubular extension 832. This tubular extension hasat its inner end a thin portion as at 833 that constitutes a frangibleconnection with the crown structure as described in connection with thevarious frangible connections mentioned in connection with thearrangements of the previously described forms of the invention.Outwards of this portion 833 is a thicker cylindrical portion 834 thatextends to an external flange 835 that receives a luer lock. Projectingbeyond the flange 835 there is a luer taper portion 836 as in the otherforms of the invention.

FIGS. 24 and 25 illustrate a connector member 837 that is a separatelymolded element. This connector member includes a base 838 from one sideof which extends an enlarged sleeve portion 839 that is internallythreaded at 840 for cooperative connection with external threads on arubber plunger or stopper of a medicament containing vial. The exteriorof the sleeve portion 839 is provided with equi-spaced ribs and flutes841 and 842, respectively, for strengthening purposes. Projecting fromthe other side of base 838 is a tubular extension structure 843 thatincludes a cylindrical portion 844 that is provided at 845 with a riband flute formation for cooperation with the rib and flute formation 815of the sleeve structure 804 of the barrel member of FIG. 21. Beyond therib and flute formation, the tubular extension is provided with anexternal groove formation 846 that provides the female part of a snaplock connection with the bead or flange 812 on the sleeve structure 804.The surface of the base 838 outwards of the extension structure willbear against the end surface 815 of sleeve structure 804 and be sonicwelded thereto if the plastic of the connector member is polypropylene.

The extension structure 843 also includes an inner conical sleeveportion 847 that merges with and extends inwards of a conical outerinternal bore portion 848 of the tubular extension. This internalconical configuration serves and center' the guide a liquid transfertube and piercing spike member that is epoxy bonded in the pocketstructure of the crown member of FIG. 22. sonic In FIG. 26, thecomponents of FIGS. 21 to 25 are illustrated in assembled and connectedrelationship together with a luer lock, a needle hub, a needle guard andan end cap. Thus, the barrel member 800 with its integral sleevestructure 804 has a connector assembly fit within the outer end of thesleeve structure 804 and connected thereto by a snap lock connectionbetween ring 812 and groove 846. If the plastics are compatible, a xonicweld connection can also be effected as diagrammatically shown at SW.The rib and flute formation between the inner surface of sleevestructure 804 and the outer surface of the sleeve extension 844 are inmating force fit engagement so that there can be no relative rotationbetween the connector structure and internal sleeve structure. Aseparately molded crown member has a liquid transfer tube means TT epoxybonded at EB in the pocket structure defined in sleeve structure 819 ofthe crown member. The assembled and connected crown member and transfertube means are then fit within the barrel member with the mating rib andflute formations on the interior of the inner end of sleeve 804 and theexterior of sleeve structure providing a force fit relationshippreventing relative turning movement. The pointed tip of the transfertube means is guided and centered during assembly by the internal taperprovided by surfaces 848 and 847 of the inner extension of the connectormember. The crown member is forced into the sleeve structure 804 untilthe flange 820 thereof snaps into groove 808 of the internal sleevestructure of the barrel member to form a snap lock connection. The bead811 on the interior of the sleeve structure 804 presses into theexterior of sleeve structure 818 to provide a sterility seal. If theplastic materials of the crown member and barrel are compatible, sonicweld connection can be effected as diagrammatically shown at SW1. Inthis event, relatively pointed energy directing bead or series ofpointed projections can be provided in the end face of flange 820 or theadjacent surface of the tube structure 804. In a sonic weld arrangement,the bead 811 would also be sonically bonded. A luer lock 848 isconnected to the flange 835 of extension 832 by adhesive bonding or asonic weld. The internal threads of the luer lock receive the flange onthe end of the needle hub 849 that is internally tapered to fit over theluer taper portion of the extension 832. A conventional needle cover 850is fit over the luer lock to cover the recipient needle 851 and a shapedend cap 852 including radially spaced sleeve portions 853 and 854 is fitinto the outer end of the barrel member with the exterior of sleeveportion 853 engaging the inner surface of the outer wall of the barrelmember and the exterior of sleeve portion 853 engaging the threads ofthe connector member. The end cap is removed when the hypodermic syringebody structure is to be associated with a medicament vial.

FIG. 27 illustrates a modified version of the structure of FIG. 26 inwhich a barrel member 860 includes an outer wall 861, a base 862 and anintegral inwardly extending internal sleeve or tubular structure 863. Ashaped crown member 864 includes a base 865 having two concentric sleeveportions 866 and 867 projecting from one face of the base and a tubularextension 868 projecting from the other face of the base. The extension868 is provided with a frangible portion 869, a flange 870 to beconnected with a luer lock not shown, and an outer luer taper portion871. The barrel base 862 is recessed at 872 to receive a rim or flange873 on the base 865 of the crown member. Energy directing pointedprojection means are provided on either the base recess surface or thesurface of flange 873 so that the crown member 864 can be sonicallywelded to the barrel member when both members are polypropylene. Such asonic weld connection is diagrammatically shown at 874. The inner boreof sleeve portion 867 is shaped to provide an epoxy resin receivingpocket 875 having ribs 876 therein so that a transfer tube 877 can beepoxy bonded in place as at 878. The outer end of the inner tubularsleeve structure 863 has an integrally formed connector portion 879having internal threads 880 and an integral web 881 having a tubularextension 882 that is shaped to provide a tapered centering well orguide bore 883 for guiding and centering the spike end of the transfertube 877 when the assembly of transfer tube and crown member are beingfit within the barrel member. In this connection, rib and fluteformations can be provided on the exterior of sleeve structure 866 andon the interior of an inner portion of sleeve structure 863 as in theforms shown in FIGS. 21 and 22. Also, a sterility seal bead like bead811, FIG. 21, can be provided.

In both forms of the invention shown in FIGS. 26 and 27, the tubularextension that projects beyond the base of the barrel member and whichincludes a frangible break-off portion is integral with the crownmember. The crown member is a separately molded tubular member or meansthat includes a surface that fits within the tubular portion or sleevestructure that is integral with the base of the barrel member.

Also, if desired, strengthening ribs could be molded on the exterior ofthe sleeve structure that is integral with the base of the barrelsimilar to the rib formations 23 in FIG. 3 and 7 in FIG. 1.

The form of invention illustrated in FIGS. 28 to 31 combines some of thefeatures shown in FIGS. 21 and 27, but utilizes a crown member having anouter tubular extension shaped to receive a fixed recipient needle.

Thus, in FIG. 28, the barrel member 900 molded from plastic material,such as polypropylene, includes an outer wall 901 having at its outerend a lateral rim or extension structure 902 to be grasped by the usersfingers when the syringe body structure is associated with a medicamentvial. The base 903 of the barrel is molded integrally with an inwardlyextending tubular sleeve portion 904 that extends throughout the barreland terminates on a level with the outer end of the barrel. The outerend of tubular sleeve portion 904 is formed similar to the arrangementof FIG. 27 and includes an integrally formed connector portion 905having internal threads 906. Inwards of the thread formation is anintegrally formed conically shaped centering well and bore structure 907for guiding and centering the spike end. of a liquid transfer tube whenan assembly of crown member and transfer tube is being fit within thebarrel. The end of the sleeve structure 904 that is adjacent the 'base903 of the barrel is shaped to receive the crown member of FIG. 29 andincludes a short inwardly tapered portion 908 leading to an internalgroove formation 909. The groove formation includes a transverse portion910, base portion 911 that is parallel to the outer wall of the barrel,and an inner angled side wall portion 912. The angularity of wallportion 912 is the same as a portion of a bead on the crown memberdescribed hereinafter. Beyond the groove formation,the inner wall of thesleeve structure is fluted at 913 to provide a ribbed formation.Inwardly of the rib formation is an internal bead 914 that engages theouter surface of the crown structure to form a sterility seal. betweenThe polypropylene crown structure or member of FIG. 29 includes a base915 from one side of which extends integrally formed outer and innertubular structures 916 and 917. The outer surface of outer tubularstructure 916 has a shaped external flange or bead structure 918 thatconforms with and fits within groove formation 909 to form a snap lockconnection etween the crown structure and the barrel member. Beyond thebead structure is a ribbed formation 919 that mates with the fluted orribbed formation 913 of the sleeve structure of the barrel member so asto prevent any turning of the crown member relative to the sleevestructure. The inner tubular or sleeve structure 917 has a slightlyinwardly tapered outer wall surface 920 and a shaped internal boreformation. The outer portion of the bore has three contiguous inwardlystepped portions of decreasing diameter 921, 922 and 923. Centrally ofthe length of each stepped portion is an internal bead 924. Theinnermost stepped portion emerges with a straight bore portion 925 thatstops at an internal shoulder 926. The bore formation constitutes asocket for a liquid transfer tube 927 having a piercing spike 928 at itsouter end. The transfer tube is epoxy bonded in place similarly to thearrangement shown in FIGS. 22 and 26.

Projecting outwardly of and integral with the base 915 is a tubularextension 929. This extension has a portion of reduced thickness at 930at its inner end to constitute a frangible connection with the crownstructure or member. This formation is similar to the frangible portiondescribed with reference to all other embodiments of the invention.Outwardly of the portion 930 is a short portion 931 of greater wallthickness. Four equi-spaced ribs 932 are provided integrally with theportion 931. A shaped external flange or bead 933 is provided axiallyoutwards of the ribs 932 so as to constitute the male member of a snaplock connection with the polypropylene shell structure of FIG. 30, whichfits over the extension 929. The internal bore formation of extension929 includes an outer inwardly tapered or outwardly flared portion 934,a straight bore portion 935 terminating at an internal shoulder 936, andanother straight bore portion 937 communicating with the interior ofbore portion 925 of the inner sleeve structure 917. The contiguous boreportions 934 and 935 together constitute a partial socket and pocketarrangement for a fixed recipient needle 938 that is epoxy bonded inplace. To complete the epoxy well or socket, the shell 939 of FIG. 30 issnap fit over extension 929. This molded shell 939 includes at its innerend an inwardly tapered inner wall portion 940 leading to an internalgroove formation 941 that provides the female member of a snap lockconnection to cooperate with the flange structure 933 of the tubularextension 929. Beyond the groove formation and extending toward theouter end of the shell structure is a bore portion 942 having a lengthgreater than the portion of the tubular extension that is outwardly offlange 933. This bore portion 942 terminates at an internal shoulder943. This shoulder being outwards of the flared end of extension 929functions to hold the epoxy bonding material in place when the shell issnap lock connected with the tubular extension and a needle 938 is epoxybonded in place similar to the showing in FIGS. 13 to 15.

FIG. 31 illustrates the barrel member 900, the crown member CM andassociated transfer tube 927 and fixed recipient needle 938 and shell939 assembled and snap lock connected together. A needle guard, notshown,

is fit over the exterior of the shell when the syringe body structure isfinally completely assembled under sterile conditions.

With the arrangement of FIGS. 28 to 31 varying size fixed recipientneedles can be utilized and varying size transfer tubes can be employeddue to the stepped formation of the internal bore surface of the innertubular sleeve structure 917.

Thus, this invention provides a structural relationship in which theproduction thereof is facilitated and which lends itself to proper totaldestruction after a single usage. In some forms of the invention, theouter body or barrel is provided with a relatively short inwardlyextending guide sleeve so that the molding of this barrel is facilitatedand there are no serious problems involved in disassociating moldmembers from this structure so that large scale production is possible.The separately formed inner tubular structure is likewise readilymolded, regardless of whether this structure is merely a single sleevecomponent having connecting threads at one end and a liquid transfertube socket at the other as in FIG. 4, or whether it is shaped as inFIG. 12 to receive a separately formed combined transfer tube andpiercing spike and to include a frangible portion and an outer extensionthat can be shaped as a needle socket or as a luer taper to have a luerlock adapter associated therewith. From a production viewpoint, therelationship of FIG. 18 is excellent in that the transfer tube can beextruded and connected to a molded piercing spike and this sub-assemblybonded to the tubular connector.

Actually, the form of the invention that embodies the simplest approachis that which consists of only two members; namely, the barrel having ashort internal guide sleeve and an inner tubular structure that combinesthe internally threaded connecting socket and piercing spike, regardlessof whether the extension beyond the base of the barrel is incorporatedwith either the barrel or the inner tubular structure, or whether suchextension is shaped to provide a needle socket or to constitute a luertaper to receive a luer lock adapter. In addition, the inventioncontemplates the provision of energy directing beads or pointedprojections on any surface extending laterally of the axis of thebarrel, regardless of whether they are on outer or inner elements sothat when the several components, after initial and separate moldingfrom compatible plastics, are assembled and exposed to sonic weldingapparatus, the effective integral bonding and. sealing of the parts toone another can be accomplished.

As this invention may be embodied in several forms without departingfrom the spirit or essential characteristics thereof, the presentembodiment is therefore illustrative and not restrictive, and since thescope of the invention is defined by the appended claims, all changesthat fall within the metes and bounds of the claims or that form theirfunctional as well as conjointly cooperative equivalents are thereforeintended to be embraced by those claims.

We claim:

1. A hypodermic syringe body structure for association with a liquidmedicament container of the type including a piercable stopper having aconnector thereon, said body structure comprising a molded plasticbarrel means open at one end and including an outer wall, a baseopposite said open end and an integral tubular portion extendinginwardly of the base toward said open end in spaced relation to saidouter wall, a separately molded inner tubular means having a wallportion fitting within at least a portion of said integral tubularportion that extends inwardly of the base of the barrel means and whichis at least adjacent said base, a tubular wall structure projectingoutwardly of said base coaxially of the inner tubular means andincluding an outer portion for operative association with a separatecannula, means defining a frangible portion disposed inwards of saidouter portion and outwards of said base so that said outer portionstructure and an associated cannula can be broken away from said barrelmeans after a single use, means effectively interconnecting saidseparately molded inner tubular means to said integral tubular portionthat extends inwardly of said base, tubular connector means foroperative coupling connection with the connector on a stopper of such amedicament container, said inner tubular means having an elongate,reduced diameter bore therein, a liquid transfer tube means supported insaid inner tubular means substantially coaxial therewith and spacedtherefrom over a major portion of the length thereof, an elongateportion of said transfer tube means fitted and rigidly supported in saidreduced diameter bore, said transfer tube means being separate from saidcannula and operatively connected between said connector and saidtubular wall structure for transferring liquid from said connector tosaid tubular wall structure and thus to a cannula that is associatedtherewith, a hollow stopper piercing spike means operatively connectedwith said liquid transfer tube means and disposed within said tubularconnector means for cooperative relation with a stopper of such amedicament container, and said tubular connector means being operativelycarried by one of said separately molded tubular means and said integraltubular portion that extends inwardly of said base of said barrelmember.

2. A hypodermic syringe body as claimed in claim 1, and stiffening ribsintegral with said barrel and extend ing from said base to said integraltubular portion.

3. A hypodermic syringe body structure as claimed in claim 1 in whichsaid barrel member and inner tubular means have mutual laterallyextending facing bonding surfaces.

4. A hypodermic syringe body structure as claimed in claim 3 and themeans interconnecting said inner tubular means and integral tubularportion comprising a sonically welded connection located at least atsaid facing bonding surfaces so that said members are effectivelyintegrally combined together.

5. A hypodermic syringe body structure as claimed in claim 3 in whichsaid bonding surfaces include facing surfaces on each member extendinglaterally of the longitudinal axis of said body structure and the meansinterconnecting said members together comprising a sonically weldedconnection located at least at said facing surfaces so that said membersare effectively integrally combined together.

6. A hypodermic syringe body structure as claimed in claim 1 in whichthe integral tubular portion extends inwardly from the base a distancethat is relatively short in relation to the length of said barrelmember.

7. A hypodermic syringe body structure as claimed in claim 1 in whichsaid means defining a stopper piercing spike member is a separatelymolded tubular plastic member having a tip at one end, said liquidtransfer tube means comprising a separately molded plastic tube havingan end portion fitting within said inner tubular means and another endportion fitting said tubular plastic stopper piercing spike member,means effectively bonding said liquid transfer tube to said tubularplastic stopper piercing spike member and to said inner tubular meansand said stopper piercing spike member to said inner tubular meansinwardly of said connector.

8. A hypodermic syringe body structure as claimed in claim 1 in whichsaid tubular connector means is an enlarged internally threaded portionat said one end of said inner tubular means and includes a base portionhaving a recess therein, said means defining a stopper piercing spikecomprising a separately molded tubular plastic member having a piercingtip at one end, a laterally extending flange inwardly of said tip anddisposed in said recess, and a tubular extension projecting beyond saidflange, said liquid transfer tube means comprising a separately moldedmember fitting said lastmentioned tubular extension and within saidfirstmentioned molded plastic inner tubular means, said flange of saidmolded plastic stopper piercing member, said base portion of saidconnector and one end of said liquid transfer tube means having mutualfacing bonding surfaces, said transfer tube means and saidfirstmentioned inner tubular means having mutual facing bonding surfacesand means effectively bonding all said members together at least at saidfacing surface.

9. A hypodermic syringe body structure as claimed in claim 1 in whichsaid tubular connector means is a separately molded plastic connectormember having internal threads thereon and means operatively connectingsaid separately molded plastic member with said integral tubular portionthat extends inwardly of said base.

10. A hypodermic syringe body structure as claimed In claim 1 in whichsaid integral tubular portion that extends inwardly of the base includesan outer end portion having internal threads thereon and which outer endportion terminates at least adjacent said open end of said barrel meansso as to constitute said tubular connector means as an integral part ofsaid integral tubular portion.

11. A hypodermic syringe body structure as claimed in claim 1 in whichsaid tubular connector means is a separately molded plastic connectormember having internal threadsthereon and means operatively connectingsaid separately molded plastic connector member with said separatelymolded tubular means.

12. A hypodermic syringe body structure as claimed in claim 1 in whichsaid separately molded tubular means includes an outer end portionhaving internal threads thereon and which outer end portion terminatesat least adjacent said open end of said barrel means so as to constitutesaid tubular connector means as an integral part of said separatelymolded tubular means.

13. A hypodermic syringe body structure .as claimed in claim 1 in whichsaid tubular connector means is a separately molded plastic connectormember including a base having an aperture therein, a tubular extensionsurrounding said aperture and projecting from one side of said base, alarger diameter internally threaded wall structure projecting from theopposite side of said base, one of said separately molded tubular meansand said integral tubular portion that extends inwardly of said base ofsaid barrel member having a terminal end portion disposed inwards of theopen end of said barrel, said tubular extension fitting within saidterminal end portion, and means effectively connecting said tubularextension with said terminal end portion.

14. A hypodermic syringe body structure as claimed in claim 13 in whichsaid tubular extension includes a shaped internal wall surface taperinginwardly toward the base of said plastic connector member for centeringsaid stopper piercing spike means.

15. A hypodermic syringe body structure as claimed in claim 1 in whichsaid tubular connecting means has internal threads for cooperation withexternal threads on a stopper of a medicament vial, said liquid transfertube means having an outer end portion, said stopper piercing spikemeans being a separately molded plastic member having a tubular endportion coaxially related with and extending axially inwards of theouter end of said liquid transfer tube means and a smaller diameteropposite end portion terminating in a stopper piercing tip coaxiallywithin said tubular connector means, and means connecting said tubularend portion to said outer end portion of said liquid transfer tube meansso as to permit said tubular end portion to turn relative to said liquidtransfer tube means when the threads on such a stopper are being engagedwith the threads on said tubular connecting means.

16. A hypodermic syringe body structure as claimed in claim 1 in whichsaid tubular wall structure having the frangible portion is integralwith said separately molded tubular means, said tubular connector meansbeing integral with said integral tubular portion that extends inwardlyof said base of said barrel member, said outer portion of said tubularwall structure having an outwardly flared bore portion for receiving aseparate cannula, an external shaped flange on said tubular wallstructure axially inwards of said flared bore portion and outwards ofsaid frangible portion and constituting the male member of a snap lockconnection, a separately molded shell member having an internal flangeadjacent one end and an internal groove formation adjacent the other endthat constitutes the female member of a snap lock connection, said shellmember being dimensioned to fit over said tubular wall structure withthe male and female members of said snap lock connection in engagementand said internal flange disposed axially outwards of the end of saidtubular wall structure so as to define with said outwardly flaredportion a bonding material receiving and confining pocket, a cannula insaid pocket and bonding material bonding the cannula in place.

17. A hypodermic syringe body structure for as'socia tion with a liquidmedicament contauner of the type container a pierceable stopper having aconnector thereon, said body structure comprising a molded plasticbarrel member having an open end, a base opposite said open end havingan aperture therethrough and an integral guide sleeve surrounding theaperture in said base and extending inwardly of said base a distancethat is relatively short in relation to the axial extent of said barrelmember, a molded plastic inner tubular member having a connector at oneend for cooperation with and connection to the connector of such amedicament container, said inner tubular member including a portionfitting within said guide sleeve of said barrel member, said innertubular member also having a base at its other end having a boretherethrough and an'integral tube-receiving sleeve extending inwardly ofsaid second-mentioned base, and communicating with said bore, said baseand sleeve including aligned inner wall portions defining a bondingmaterial receiving pocket and a tube-receiving bore in inwardcontinuation of said pocket and of less cross-sectional area than saidpocket, a liquid transfer tube having an intermediate portion disposedthrough said last-mentioned bore and pocket, an end portion extendingfrom said intermediate portion to terminate at least slightly beyond thebase of said barrel member and an opposite end portion terminating atleast approximately at the level of said one end of said inner tubularmember, the liquid transfer tube spaced from said inner tubular memberover a major portion of its length, said opposite end portion of saidtransfer tube being shaped to define a stopper piercing spike, bondingmeans at least within said pocket and surrounding said intermediateportion of said tube to connect said tube to said inner tubular member,said barrel member havin a tubular extension projecting outwardly of theaperture in said firstmentioned bore, said tubular extension having afrangible portion outwards of said base of said barrel member, meansoperatively connected with said tubular extension outwards of saidfrangible portion for receiving a cannula, said internal guide sleevebeing radially outwards of the aperture through the bore of said barrelmember, and means connecting the outer surface of the base of said innertubular member to an inner surface of the base of said barrel member.radially inwardly of said internal guide sleeve.

18. A hypodermic syringe body structure as claimed in claim 17 and saidconnector at one end of said inner tubular member comprising aninternally threaded portion extending inwardly from said one end.

19. A hypodermic syringe body structure as claimed in claim 17 andcircumferentially spaced integral stiffening rib means extending betweenthe base of said barrel member and said internal guide sleeve.

20. A hypodermic syringe body structure as claimed in claim 17 andcircumferentially spaced stiffening ribs integral with said innertubular member and extending radially outwards of and along the exteriorof said member throughout the major axial extent thereof.

21. A hypodermic syringe body structure for association with a liquidmedicament container of the type including a pierceable stopper having aconnector thereon, said body structure comprising a molded plasticbarrel member having an open end, a base opposite said open end havingan aperture therethrough and an integral, internal guide sleevesurrounding the aperture in said base and extending inwardly of saidbase a distance that is relatively short in relation to the axial extentof said barrel member, a molded plastic inner tubular member having anintermediate portion fitting within said guide sleeve, a connector meansat one end of said inner tubular member for cooperation with andconnection to the connector of such a medicament container and a tubularextension portion in continuation of said intermediate portion andprojecting outwardly of the base of said barrel member, said tubularextension portion having a frangible portion outwards of said base ofsaid barrel member, means operatively connected with said tubularextension portion outwards of said frangible portion for receiving acannula, a molded plastic liquid transfer tube fitting within said innertubular member and having an end portion terminating at leastapproximately at the level of said one end of said inner tubularportion, said end portion of said transfer tube being shaped to define astopper piercing spike, said internal guide sleeve and inner tubularmember having mutually facing bonding surfaces extending laterally ofthe major axes of said members, said liquid transfer tube having atleast one bonding surface extending laterally of the major axis thereof,said inner tubular member also having at least one laterally extendingbonding surface facing said bonding surface of said transfer tube, andmeans connecting said transfer tube to said inner tubular member andsaid inner tubular member to said barrel member at least at said bondingsurfaces.

22. A hypodermic syringe body structure as claimed in claim 21 andcircumferentially spaced integral stiffening ribs extending between saidbase of said barrel member and said internal guide sleeve.

23. A hypodermic syringe body structure as claimed in claim 21 and saidconnector means at said one end of said inner tubular member comprisingan internally threaded portion extending inwardly from said one end.

24. A hypodermic syringe body structure as claimed in claim 21 and saidinner tubular member having stepped internal diameter portionsincreasing in size inwardly from the end thereof remote from saidconnector means including a portion of an internal diameter greater thanthe external diameter of said transfer tube and extending axially ofsaid inner tubular member for a substantial extent thereof between saidinternal guide sleeve and said connector means, and said plastic liquidtransfer tube having integral circumferentially spaced stiffening ribsextending radially outwards of said transfer tube over a substantialaxial extent of the portion thereof that extends between said internalguide sleeve and said connector.

25. A hypodermic syringe body structure as claimed in claim 24 andintegral circumferentially spaced stiffening ribs extending radiallyoutwards of said inner tubular member over at least a substantiallongitudinal extent thereof between said internal guide sleeve and saidconnector.

26. A hypodermic syringe body structure as claimed in claim 21 and saidinternal guide sleeve having stepped internal surface portions ofdifferent crosssectional areas including a first internal surfaceportion extending inwardly from said base of said barrel member and asecond internal surface portion extending longitudinally inwardly fromsaid first internal surface portion, said surface portions beingseparated by an internal shoulder on said internal guide sleeve, saidinner tubular member having stepped external surface portions and anexternal shoulder complementary with said internal stepped surfaceportions and internal shoulder of said internal guide sleeve.

27. A hypodermic syringe body structure as claimed in claim 26 and saidfirst stepped internal surface portion of said internal guide sleeve andthe complementary external surface portion of said inner tubular memberbeing polygonal in cross section.

28. A hypodermic syringe body structure for association with a liquidmedicament container of the type including a pierceable stopper havingan externally threaded connector portion, said body structure comprisinga molded plastic barrel means open at one end and including an outerwall, a base opposite said one end and an integral tubular portionextending inwardly of said base toward said open end, a separatelymolded tubular means constituting a crown member and including a base, aplurality of integral coaxial tubular sleeve structures projecting fromone side of said base and including at least a first sleeve structuredisposed centrally of said base and a second sleeve structure radiallyoutwards of said first sleeve structure and including an outer wallsurface, at least a portion of which fits within and contacts at least aportion of the interior of said integral tubular portion, a tubularextension projecting from the opposite side of said base of said crownmember coaxially of said first sleeve structure, said tubular extensionhaving an outer portion for operative association with a separatecannula, said tubular extension including a frangible portion betweensaid outer portion and the base of said crown member so that the outerportion of said tubular extension and an associated cannula can bebroken off after a single use, said first mentioned sleeve structurehaving a shaped internal bore communicating with the interior of saidtubular extension, said shaped internal bore including an inner tubereceiving portion and an outer enlarged portion constituting a bondingmaterial receiving pocket, a liquid transfer tube having at least aportion disposed within said pocket, bonding material within said pocketand surrounding the portion of said transfer tube disposed therein toconnect said transfer tube to said first sleeve structure and thus tosaid crown member to said barrel means, threaded connector means carriedby said integral tubular portion and located at the open end of saidbarrel means so as to connect said syringe body structure to a stopperof a medicament vial, and a hollow stopper piercing spike carried bysaid liquid transfer tube and extending within said threaded connectormeans.

29. A hypodermic syringe body structure as claimed in claim 28 in whichsaid barrel means and crown member are of compatible plastic, said baseof said barrel means having a recess therein, said base of said crownmember having a rim portion laterally outwards of said second sleevestructure, said rim portion fitting within said recess and the meansoperatively connecting said crown member to said barrel means includinga sonic weld connection between said rim and the facing surface of saidrecess.

30. A hypodermic syringe body as claimed in claim 28 in which said crownmember includes a third sleeve structure extending from said one side ofthe base of the crown member radially outwards of said second sleevestructure and having a length that is relatively short in relation tothe length of said second sleeve structure, said integral tubularportion extending inwardly of the base of the barrel means including alarger diameter portion adjacent the base of the barrel means, saidlarger diameter portion having an internal annular groove therein, saidthird sleeve structure having an external projecting annular beadformation for cooperative association within said groove to provide asnap lock connection between said crown member and said barrel means.

31. A hypodermic syringe structure as claimed in claim 28 in which saidconnector means comprises an integral internally threaded outer portionof said integral tubular portion that extends inwardly of the base ofsaid barrel member, a web structure within said integral tubular portionand located inwards of said internally threaded portion, an integraltubular extension of said web structure facing the base end of saidbarrel means and having a bore surface tapering inwardly toward the openend of said barrel means for guiding and centering the piercing spikewhen the crown member and associated liquid transfer tube and piercingspike are fitted within said integral tubular portion that extendsinwards of the base of said barrel means.

32. A hypodermic syringe body structure as claimed in claim 28, saidintegral tubular portion having an inwardly directed annular beadformation located in inward spaced relation to the outer end of saidtubular portion, said connector means comprising a separately moldedplastic connector member including a base, an internally threaded sleeveportion extending from one side of the base of the connector member forcooperation with the externally threaded portion of the stopper of amedicament container, a tubular extension structure projecting from theother side of the base of said connector member, said tubular extensionstructure including a cylindrical portion having an internal annulargroove therein for cooperative engagement with the internal beadstructure on said integral tubular portion to provide a snap lockconnection between said connector member and said integral tubularportion, said tubular extension structure having a bore surface taperinginwardly toward the base of the connector member for guiding andcentering the piercing spike when the crown member and associated liquidtransfer tube and piercing spike is fit within said integral tubularportion that extends inwards of the base of said barrel means.

33. A hypodermic syringe body structure as claimed in claim 28 in whichsaid tubular extension projecting from the opposite side of said base ofsaid crown member includes an end, an externally shaped flange meansaxially outwards of said frangible portion and constituting the malemember of a snap lock connection, said tubular extension having anoutwardly flared bore portion leading to its end for receiving aseparate cannula, a separately molded shell member having an internalflange adjacent one end and an internal groove formation adjacent theother end that constitutes the female member of a snap lock connection,said shell member being dimensioned to fit over said tubular extensionwith the male and female members of said snap lock connection inengagement and said internal flange disposed axially outwards of the endof said tubular extension so as to define with said outwardly flaredportion a bonding material receiving and confining pocket,a cannula insaid pocket and bonding material bonding the cannula in place.

34. A hypodermic syringe body structure as claimed inclaim 28 in whichsaid connector means comprises an integral internally threaded outerportion of said integral tubular portion that extends inwardly of thebase of said barrel member, an integral tubular structure within saidintegral tubular portion and located inwards of said internally threadedportion, said integral tubular structure facing the base end of saidbarrel means and having a bore surface tapering inwardly toward the openend of said barrel means for guiding and centering the piercing spikewhen the crown member andassociated liquid transfer tube and piercingspike are fitted within said integral tubular portion that extendsinwards of the base of said barrel means.

1. A hypodermic syringe body structure for association with a liquidmedicament container of the type including a pierceable stopper having aconnector thereon, said body structure comprising a molded plasticbarrel means open at one end and including an outer wall, a baseopposite said open end and an integral tubular portion extendinginwardly of the base toward said open end in spaced relation to saidouter wall, a separately molded inner tubular means having a wallportion fitting within at least a portion of said integral tubularportion that extends inwardly of the base of the barrel means and whichis at least adjacent said base, a tubular wall structure projectingoutwardly of said base coaxially of the inner tubular means andincluding an outer portion for operative association with a separatecannula, means defining a frangible portion disposed inwards of saidouter portion and outwards of said base so that said outer portionstructure and an associated cannula can be broken away from said barrelmeans after a single use, means effectively interconnecting saidseparately molded inner tubular means to said integral tubular portionthat extends inwardly of said base, tubular connector means foroperative coupling connection with the connector on a stopper of such amedicament container, said inner tubular means having an elongate,reduced diameter bore therein, a liquid transfer tube means supported insaid inner tubular means substantially coaxial therewith and spacedtherefrom over a major portion of the length thereof, an elongateportion of said transfer tube means fitted and rigidly supported in saidreduced diameter bore, said transfer tube means being separate from saidcannula and operatively connected between said connector and saidtubular wall structure for transferring liquid from said connector tosaid tubular wall structure and thus to a cannula that is associatedtherewith, a hollow stopper piercing spike means operatively connectedwith said liquid transfer tube means and disposed within said tubularconnector means for cooperative relation with a stopper of such amedicament container, and said tubular connector means being operativelycarried by one of said separately molded tubular means and said integraltubular portion that extends inwardly of said base of said barrelmember.
 2. A hypodermic syringe body as claimed in claim 1, andstiffening ribs integral with said barrel and extending from sAid baseto said integral tubular portion.
 3. A hypodermic syringe body structureas claimed in claim 1 in which said barrel member and inner tubularmeans have mutual laterally extending facing bonding surfaces.
 4. Ahypodermic syringe body structure as claimed in claim 3 and the meansinterconnecting said inner tubular means and integral tubular portioncomprising a sonically welded connection located at least at said facingbonding surfaces so that said members are effectively integrallycombined together.
 5. A hypodermic syringe body structure as claimed inclaim 3 in which said bonding surfaces include facing surfaces on eachmember extending laterally of the longitudinal axis of said bodystructure and the means interconnecting said members together comprisinga sonically welded connection located at least at said facing surfacesso that said members are effectively integrally combined together.
 6. Ahypodermic syringe body structure as claimed in claim 1 in which theintegral tubular portion extends inwardly from the base a distance thatis relatively short in relation to the length of said barrel member. 7.A hypodermic syringe body structure as claimed in claim 1 in which saidmeans defining a stopper piercing spike member is a separately moldedtubular plastic member having a tip at one end, said liquid transfertube means comprising a separately molded plastic tube having an endportion fitting within said inner tubular means and another end portionfitting said tubular plastic stopper piercing spike member, meanseffectively bonding said liquid transfer tube to said tubular plasticstopper piercing spike member and to said inner tubular means and saidstopper piercing spike member to said inner tubular means inwardly ofsaid connector.
 8. A hypodermic syringe body structure as claimed inclaim 1 in which said tubular connector means is an enlarged internallythreaded portion at said one end of said inner tubular means andincludes a base portion having a recess therein, said means defining astopper piercing spike comprising a separately molded tubular plasticmember having a piercing tip at one end, a laterally extending flangeinwardly of said tip and disposed in said recess, and a tubularextension projecting beyond said flange, said liquid transfer tube meanscomprising a separately molded member fitting said last-mentionedtubular extension and within said first-mentioned molded plastic innertubular means, said flange of said molded plastic stopper piercingmember, said base portion of said connector and one end of said liquidtransfer tube means having mutual facing bonding surfaces, said transfertube means and said first-mentioned inner tubular means having mutualfacing bonding surfaces and means effectively bonding all said memberstogether at least at said facing surface.
 9. A hypodermic syringe bodystructure as claimed in claim 1 in which said tubular connector means isa separately molded plastic connector member having internal threadsthereon and means operatively connecting said separately molded plasticmember with said integral tubular portion that extends inwardly of saidbase.
 10. A hypodermic syringe body structure as claimed in claim 1 inwhich said integral tubular portion that extends inwardly of the baseincludes an outer end portion having internal threads thereon and whichouter end portion terminates at least adjacent said open end of saidbarrel means so as to constitute said tubular connector means as anintegral part of said integral tubular portion.
 11. A hypodermic syringebody structure as claimed in claim 1 in which said tubular connectormeans is a separately molded plastic connector member having internalthreads thereon and means operatively connecting said separately moldedplastic connector member with said separately molded tubular means. 12.A hypodermic syringe body structure as claimed in claim 1 in which saidseparately molded tubular means includes an outer end portion havinginternal Threads thereon and which outer end portion terminates at leastadjacent said open end of said barrel means so as to constitute saidtubular connector means as an integral part of said separately moldedtubular means.
 13. A hypodermic syringe body structure as claimed inclaim 1 in which said tubular connector means is a separately moldedplastic connector member including a base having an aperture therein, atubular extension surrounding said aperture and projecting from one sideof said base, a larger diameter internally threaded wall structureprojecting from the opposite side of said base, one of said separatelymolded tubular means and said integral tubular portion that extendsinwardly of said base of said barrel member having a terminal endportion disposed inwards of the open end of said barrel, said tubularextension fitting within said terminal end portion, and meanseffectively connecting said tubular extension with said terminal endportion.
 14. A hypodermic syringe body structure as claimed in claim 13in which said tubular extension includes a shaped internal wall surfacetapering inwardly toward the base of said plastic connector member forcentering said stopper piercing spike means.
 15. A hypodermic syringebody structure as claimed in claim 1 in which said tubular connectingmeans has internal threads for cooperation with external threads on astopper of a medicament vial, said liquid transfer tube means having anouter end portion, said stopper piercing spike means being a separatelymolded plastic member having a tubular end portion coaxially relatedwith and extending axially inwards of the outer end of said liquidtransfer tube means and a smaller diameter opposite end portionterminating in a stopper piercing tip coaxially within said tubularconnector means, and means connecting said tubular end portion to saidouter end portion of said liquid transfer tube means so as to permitsaid tubular end portion to turn relative to said liquid transfer tubemeans when the threads on such a stopper are being engaged with thethreads on said tubular connecting means.
 16. A hypodermic syringe bodystructure as claimed in claim 1 in which said tubular wall structurehaving the frangible portion is integral with said separately moldedtubular means, said tubular connector means being integral with saidintegral tubular portion that extends inwardly of said base of saidbarrel member, said outer portion of said tubular wall structure havingan outwardly flared bore portion for receiving a separate cannula, anexternal shaped flange on said tubular wall structure axially inwards ofsaid flared bore portion and outwards of said frangible portion andconstituting the male member of a snap lock connection, a separatelymolded shell member having an internal flange adjacent one end and aninternal groove formation adjacent the other end that constitutes thefemale member of a snap lock connection, said shell member beingdimensioned to fit over said tubular wall structure with the male andfemale members of said snap lock connection in engagement and saidinternal flange disposed axially outwards of the end of said tubularwall structure so as to define with said outwardly flared portion abonding material receiving and confining pocket, a cannula in saidpocket and bonding material bonding the cannula in place.
 17. Ahypodermic syringe body structure for association with a liquidmedicament container of the type container a pierceable stopper having aconnector thereon, said body structure comprising a molded plasticbarrel member having an open end, a base opposite said open end havingan aperture therethrough and an integral guide sleeve surrounding theaperture in said base and extending inwardly of said base a distancethat is relatively short in relation to the axial extent of said barrelmember, a molded plastic inner tubular member having a connector at oneend for cooperation with and connection to the connector of such amedicament containEr, said inner tubular member including a portionfitting within said guide sleeve of said barrel member, said innertubular member also having a base at its other end having a boretherethrough and an integral tube-receiving sleeve extending inwardly ofsaid second-mentioned base, and communicating with said bore, said baseand sleeve including aligned inner wall portions defining a bondingmaterial receiving pocket and a tube-receiving bore in inwardcontinuation of said pocket and of less cross-sectional area than saidpocket, a liquid transfer tube having an intermediate portion disposedthrough said last-mentioned bore and pocket, an end portion extendingfrom said intermediate portion to terminate at least slightly beyond thebase of said barrel member and an opposite end portion terminating atleast approximately at the level of said one end of said inner tubularmember, the liquid transfer tube spaced from said inner tubular memberover a major portion of its length, said opposite end portion of saidtransfer tube being shaped to define a stopper piercing spike, bondingmeans at least within said pocket and surrounding said intermediateportion of said tube to connect said tube to said inner tubular member,said barrel member having a tubular extension projecting outwardly ofthe aperture in said first-mentioned bore, said tubular extension havinga frangible portion outwards of said base of said barrel member, meansoperatively connected with said tubular extension outwards of saidfrangible portion for receiving a cannula, said internal guide sleevebeing radially outwards of the aperture through the bore of said barrelmember, and means connecting the outer surface of the base of said innertubular member to an inner surface of the base of said barrel memberradially inwardly of said internal guide sleeve.
 18. A hypodermicsyringe body structure as claimed in claim 17 and said connector at oneend of said inner tubular member comprising an internally threadedportion extending inwardly from said one end.
 19. A hypodermic syringebody structure as claimed in claim 17 and circumferentially spacedintegral stiffening rib means extending between the base of said barrelmember and said internal guide sleeve.
 20. A hypodermic syringe bodystructure as claimed in claim 17 and circumferentially spaced stiffeningribs integral with said inner tubular member and extending radiallyoutwards of and along the exterior of said member throughout the majoraxial extent thereof.
 21. A hypodermic syringe body structure forassociation with a liquid medicament container of the type including apierceable stopper having a connector thereon, said body structurecomprising a molded plastic barrel member having an open end, a baseopposite said open end having an aperture therethrough and an integral,internal guide sleeve surrounding the aperture in said base andextending inwardly of said base a distance that is relatively short inrelation to the axial extent of said barrel member, a molded plasticinner tubular member having an intermediate portion fitting within saidguide sleeve, a connector means at one end of said inner tubular memberfor cooperation with and connection to the connector of such amedicament container and a tubular extension portion in continuation ofsaid intermediate portion and projecting outwardly of the base of saidbarrel member, said tubular extension portion having a frangible portionoutwards of said base of said barrel member, means operatively connectedwith said tubular extension portion outwards of said frangible portionfor receiving a cannula, a molded plastic liquid transfer tube fittingwithin said inner tubular member and having an end portion terminatingat least approximately at the level of said one end of said innertubular portion, said end portion of said transfer tube being shaped todefine a stopper piercing spike, said internal guide sleeve and innertubular member having mutually facing bonding surfaces extendinglatErally of the major axes of said members, said liquid transfer tubehaving at least one bonding surface extending laterally of the majoraxis thereof, said inner tubular member also having at least onelaterally extending bonding surface facing said bonding surface of saidtransfer tube, and means connecting said transfer tube to said innertubular member and said inner tubular member to said barrel member atleast at said bonding surfaces.
 22. A hypodermic syringe body structureas claimed in claim 21 and circumferentially spaced integral stiffeningribs extending between said base of said barrel member and said internalguide sleeve.
 23. A hypodermic syringe body structure as claimed inclaim 21 and said connector means at said one end of said inner tubularmember comprising an internally threaded portion extending inwardly fromsaid one end.
 24. A hypodermic syringe body structure as claimed inclaim 21 and said inner tubular member having stepped internal diameterportions increasing in size inwardly from the end thereof remote fromsaid connector means including a portion of an internal diameter greaterthan the external diameter of said transfer tube and extending axiallyof said inner tubular member for a substantial extent thereof betweensaid internal guide sleeve and said connector means, and said plasticliquid transfer tube having integral circumferentially spaced stiffeningribs extending radially outwards of said transfer tube over asubstantial axial extent of the portion thereof that extends betweensaid internal guide sleeve and said connector.
 25. A hypodermic syringebody structure as claimed in claim 24 and integral circumferentiallyspaced stiffening ribs extending radially outwards of said inner tubularmember over at least a substantial longitudinal extent thereof betweensaid internal guide sleeve and said connector.
 26. A hypodermic syringebody structure as claimed in claim 21 and said internal guide sleevehaving stepped internal surface portions of different cross-sectionalareas including a first internal surface portion extending inwardly fromsaid base of said barrel member and a second internal surface portionextending longitudinally inwardly from said first internal surfaceportion, said surface portions being separated by an internal shoulderon said internal guide sleeve, said inner tubular member having steppedexternal surface portions and an external shoulder complementary withsaid internal stepped surface portions and internal shoulder of saidinternal guide sleeve.
 27. A hypodermic syringe body structure asclaimed in claim 26 and said first stepped internal surface portion ofsaid internal guide sleeve and the complementary external surfaceportion of said inner tubular member being polygonal in cross section.28. A hypodermic syringe body structure for association with a liquidmedicament container of the type including a pierceable stopper havingan externally threaded connector portion, said body structure comprisinga molded plastic barrel means open at one end and including an outerwall, a base opposite said open end and an integral tubular portionextending inwardly of said base toward said open end, a separatelymolded tubular means constituting a crown member and including a base, aplurality of integral coaxial tubular sleeve structures projecting fromone side of said base and including at least a first sleeve structuredisposed centrally of said base and a second sleeve structure radiallyoutwards of said first sleeve structure and including an outer wallsurface, at least a portion of which fits within and contacts at least aportion of the interior of said integral tubular portion, a tubularextension projecting from the opposite side of said base of said crownmember coaxially of said first sleeve structure, said tubular extensionhaving an outer portion for operative association with a separatecannula, said tubular extension including a frangible portion betweensaid outer portion and the base of said crown member so that the outerportion of said tubular extension and an associated cannula can bebroken off after a single use, said first mentioned sleeve structurehaving a shaped internal bore communicating with the interior of saidtubular extension, said shaped internal bore including an inner tubereceiving portion and an outer enlarged portion constituting a bondingmaterial receiving pocket, a liquid transfer tube having at least aportion disposed within said pocket, bonding material within said pocketand surrounding the portion of said transfer tube disposed therein toconnect said transfer tube to said first sleeve structure and thus tosaid crown member to said barrel means, threaded connector means carriedby said integral tubular portion and located at the open end of saidbarrel means so as to connect said syringe body structure to a stopperof a medicament vial, and a hollow stopper piercing spike carried bysaid liquid transfer tube and extending within said threaded connectormeans.
 29. A hypodermic syringe body structure as claimed in claim 28 inwhich said barrel means and crown member are of compatible plastic, saidbase of said barrel means having a recess therein, said base of saidcrown member having a rim portion laterally outwards of said secondsleeve structure, said rim portion fitting within said recess and themeans operatively connecting said crown member to said barrel meansincluding a sonic weld connection between said rim and the facingsurface of said recess.
 30. A hypodermic syringe body as claimed inclaim 28 in which said crown member includes a third sleeve structureextending from said one side of the base of the crown member radiallyoutwards of said second sleeve structure and having a length that isrelatively short in relation to the length of said second sleevestructure, said integral tubular portion extending inwardly of the baseof the barrel means including a larger diameter portion adjacent thebase of the barrel means, said larger diameter portion having aninternal annular groove therein, said third sleeve structure having anexternal projecting annular bead formation for cooperative associationwithin said groove to provide a snap lock connection between said crownmember and said barrel means.
 31. A hypodermic syringe structure asclaimed in claim 28 in which said connector means comprises an integralinternally threaded outer portion of said integral tubular portion thatextends inwardly of the base of said barrel member, a web structurewithin said integral tubular portion and located inwards of saidinternally threaded portion, an integral tubular extension of said webstructure facing the base end of said barrel means and having a boresurface tapering inwardly toward the open end of said barrel means forguiding and centering the piercing spike when the crown member andassociated liquid transfer tube and piercing spike are fitted withinsaid integral tubular portion that extends inwards of the base of saidbarrel means.
 32. A hypodermic syringe body structure as claimed inclaim 28, said integral tubular portion having an inwardly directedannular bead formation located in inward spaced relation to the outerend of said tubular portion, said connector means comprising aseparately molded plastic connector member including a base, aninternally threaded sleeve portion extending from one side of the baseof the connector member for cooperation with the externally threadedportion of the stopper of a medicament container, a tubular extensionstructure projecting from the other side of the base of said connectormember, said tubular extension structure including a cylindrical portionhaving an internal annular groove therein for cooperative engagementwith the internal bead structure on said integral tubular portion toprovide a snap lock connection between said connector member and saidintegral tubular portion, said tubular extension structure having a boresurface tapering inwardly toward the base of the connector member forguiding and centering the piercing spike when the crown member andassociated liquid transfer tube and piercing spike is fit within saidintegral tubular portion that extends inwards of the base of said barrelmeans.
 33. A hypodermic syringe body structure as claimed in claim 28 inwhich said tubular extension projecting from the opposite side of saidbase of said crown member includes an end, an externally shaped flangemeans axially outwards of said frangible portion and constituting themale member of a snap lock connection, said tubular extension having anoutwardly flared bore portion leading to its end for receiving aseparate cannula, a separately molded shell member having an internalflange adjacent one end and an internal groove formation adjacent theother end that constitutes the female member of a snap lock connection,said shell member being dimensioned to fit over said tubular extensionwith the male and female members of said snap lock connection inengagement and said internal flange disposed axially outwards of the endof said tubular extension so as to define with said outwardly flaredportion a bonding material receiving and confining pocket, a cannula insaid pocket and bonding material bonding the cannula in place.
 34. Ahypodermic syringe body structure as claimed inclaim 28 in which saidconnector means comprises an integral internally threaded outer portionof said integral tubular portion that extends inwardly of the base ofsaid barrel member, an integral tubular structure within said integraltubular portion and located inwards of said internally threaded portion,said integral tubular structure facing the base end of said barrel meansand having a bore surface tapering inwardly toward the open end of saidbarrel means for guiding and centering the piercing spike when the crownmember and associated liquid transfer tube and piercing spike are fittedwithin said integral tubular portion that extends inwards of the base ofsaid barrel means.